Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption

Jack Bowden, Fabiola Del Greco M, Cosetta Minelli, Debbie Lawlor, Qingyuan Zhao, Nuala Sheehan, John Thompson, George Davey Smith

February 2018

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Abstract

This paper proposes a modified Cochran’s $Q$ statistic to detect horizontal pleiotropy in Mendelian randomization. This extension is quite important when there are many weak genetic instruments.

Type

Journal article

Publication

International Journal of Epidemiology (2019)